Дизартрична симптоматика, маркери и съпътстващи дефицити в синдрома на Паркинсон
Ключови думи :
дизартрия, дисфагия, фонация, артикулация, прозодикаРезюме
Дизартрията е състояние, което често съпътства неврологичните заболявания от централен и периферен тип (вродени и придобити). В синдрома на Паркинсон тя е сериозно предизвикателство за всеки специалист, извършващ терапевтична или изследователска дейност с подобен род патология. Сама по себе си дизартрията засяга и разстройва всички нива на органите и структурите, отговорни за говорната продукция. При редица неврологични заболявания адекватното лечение обикновено води до подобрение или ограничаване на прогреса на дизартричната симптоматика. В синдрома на Паркинсон терапията ѝ е свързана с редица трудности поради факта, че в основата на болестта стои дегенеративен разпад от централен тип, който с времето прогресира и влошава наличната симптоматика. Причината е липса на утвърдено лечение, заменено от поддържаща терапия, която да повиши качеството на живот на болните.
Материалът описва характерните за това заболяване дисфункции във всички компоненти на говора: дишане, фонация, артикулация и прозодика. Проведеният теоретичен анализ на литературата има за цел да очертае различния и комплексен характер на дизартрията при Паркинсонов синдром, допълнена в много от случаите с признаци на говорна апраксия и дисфагия.
Библиография:
Ackermann, H., & Ziegler, W. (1991). Articulatory deficits in Parkinsonian dysarthria: An acoustic analysis. Journal of Neurology, Neurosurgery & Psychiatry, 54(12), 1093–1098.
Alm, P. (2004). Stuttering and the basal ganglia circuits: a critical review of possible relations. Journal of Communication Disorders, 37, 325–369.
Arman, A., Lorente-Ramos, R. M., García, G., & Collazo Lorduy, C. (2019). Videofluoroscopic evaluation of normal and impaired oropharyngeal swallowing. Radio Graphics, 39(1), 78–79. https://doi.org/10.1148/rg.2019180070
Barnish, M. S., Horton, S. M. C., Butterfint, Z. R., Clark, A. B., Atkinson, R. A., & Deane, K. H. O. (2017). Speech and communication in Parkinson's disease: a cross-sectional exploratory study in the UK. BMJ Open, 7(5), e014642.
Bejjani, B. P., Gervais, D., Arnulf, I., Papadopoulos, S., Demeret, S., Bonnet, A. M., & et al. (2000). Axial parkinsonian symptoms can be improved: the role of levodopa and bilateral subthalamic stimulation. Journal of Neurology, Neurosurgery & Psychiatry, 68(5), 595–600. doi: 10.1136/jnnp.68.5.595
Brabenec, L., Mekyska, J., Galaz, Z., & Rektorova, I. (2017). Speech disorders in Parkinson’s disease: early diagnostics and effects of medication and brain stimulation. Journal of Neural Transmission, 124, 303–334. doi: 10.1007/s00702-017-1676-0
Branco, L. L., Trentin, S., Augustin Schwanke, C. H., Gomes, I., & Loureiro, F. (2019). The swallowing clinical assessment score in Parkinson’s disease (SCAS-PD) is a valid and low-cost tool for evaluation of Dysphagia: a gold-standard comparison study. Journal of Aging Research, 1–7. https://doi.org/10.1155/2019/7984635
Bunton, K. (2005). Patterns of lung volume use during an extemporaneous speech task in persons with Parkinson disease. Journal of Communication Disorders, 38, 331–348.
Cardoso, R., Guimarães, I., Santos, H., & et al. (2016). Frenchay Dysarthria Assessment (FDA-2) in Parkinson’s disease: cross-cultural adaptation and psychometric properties of the European Portuguese version. Journal of Neurology, 264(1), 2131. https://doi.org/10.1007/s00415-016-8298-6
Chen, Y., Zhu, G., Liu, D., Liu, Y., Yuan, T., Zhang, X., & et al. (2020). Brain morphological changes in hypokinetic dysarthria of Parkinson’s disease and use of machine learning to predict severity. CNS Neuroscience & Therapeutics, 26, 711–719. doi: 10.1111/cns.13304
Clifford, T., & Finnerty, J. (1995). The dental awareness and needs of a Parkinson’s disease population. Gerodontology, 12(12), 99–103.
Critchley, E. M. (1981). Speech disorders of Parkinsonism: A review. Journal of Neurology, Neurosurgery & Psychiatry, 44(9), 751–758. https://doi.org/10.1136/jnnp.44.9.751
Darley, F. L., Aronson, A. E., & Brown, J. R. (1969). Differential diagnostic patterns of dysarthria. Journal of Speech and Hearing Research, 12(2), 246–269.
Dashtipour, K., Tafreshi, A., Lee, J., & Crawley, B. (2018). Speech disorders in Parkinson’s disease: pathophysiology, medical management and surgical approaches. Neurodegenerative Disease Management, 8, 337–348. doi: 10.2217/nmt-2018-0021
De Nil, L. F., Rochon, E., & Jokel, R. (2009). Adult Onset Neurogenic Suttering. In: M. R. McNeil (Ed.), Clinical Management of Sensoriomotor Speech Disorders (2nd ed., pp. 235–248). Thieme.
Dromey, C. (2003). Spectral measures and perceptual ratings of hypokinetic dysarthria. Journal of Medical Speech-Language Pathology, 11, 85–94.
Duffy, J. (2005). Motor Speech Disorders: Substrates, Differential Diagnosis, and Management. Elsevier Mosby.
Duffy, J. R. (2013). Chapter 1. Motor speech disorders-E-book: substrates, differential diagnosis, and management (pp. 3–94). Elsevier Health Sciences.
Duffy, J. R. (2019). Motor Speech Disorders E-Book: Substrates, Differential Diagnosis, and Management. Elsevier Health Sciences.
Duffy, J. R. (2020). Motor Speech Disorders. Substrates, Differential Diagnosis, and Management (4th ed.). Elsevier.
Ebihara, E., Saito, H., Kanda, A., & et al. (2003). Impaired efficacy of cough in patients with Parkinson’s disease. Chest, 124(3), 1009–1015.
Forrest, K., Weismer, G., & Turner, G. S. (1989). Kinematic, acoustic, and perceptual analysis of connected speech produced by parkinsonian and normal geriatric adults. Journal of the Acoustical Society of America, 85(6), 2608–2622.
Gandhi, P., Mancopes, R., Sutton, D., Plowman, E. K., & Steele, C. M. (2021). The frequency of atypical and extreme values for pharyngeal phase swallowing measures in mild Parkinson’s disease compared to healthy aging. Journal of Speech, Language, and Hearing Research, 64(8), 3032-3050. https://doi.org/10.1044/2021_jslhr-21-00084
Gentilhomme, A., Tir, M., & Renard, A. (2020). Dysarthrie dans la maladie de Parkinson. Quelle est la sévérité de la dysarthrie au moment de la première évaluation en orthophonie pour prise en soin? Neurologies, 23, 213.
Goetz, C. G., & et al. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129–2170.
Grammatikopoulou, A., Grammalidis, N., Bostantjopoulou, S., & Katsarou, Z. (2019). Detecting hypomimia symptoms by selfie photo analysis: for early Parkinson disease detection. In: Proceedings of the 12th ACM International Conference on PErvasive Technologies Related to Assistive Environments (pp. 517–522).
Guedes, L. U., Rodrigues, J. M., Fernandes, A. A., Cardoso, F. E., & Parreira, V. F. (2012). Respiratory changes in Parkinson’s disease may be unrelated to dopaminergic dysfunction. Arquivos de Neuro-Psiquiatria, 70(11), 847–851.
Hammer, M. J. (2013). Aerodynamic assessment of phonatory onset in Parkinson’s disease: evidence of decreased scaling of laryngeal and respiratory control. Journal of Parkinson's Disease, 3(2), 173–179. https://doi.org/10.3233/JPD-130180
Hartelius, L. (2015). Dysartri - Bedömning och Intervention: vid Förvärvade Neurologiska Talstörningar hos Vuxna. Studentlitteratur.
Hirsch, L., Jette, N., Frolkis, A., Steeves, T., & Pringsheim, T. (2016). The incidence of Parkinson’s disease: a systematic review and meta-analysis. Neuroepidemiology, 46, 292–300.
Ho, A. K., Bradshaw, J. L., & Iansek, R. (2000). Volume perception in Parkinsonian speech. Movement Disorders, 15, 1125–1131. doi: 10.1002/1531-8257(200011)15:6<1125::AID-MDS1010<3.0.CO;2-R
Hoodin, R. B., & Gilbert, H. R. (1989). Nasal airflows in parkinsonian speakers. Journal of Communication Disorders, 22, 169–180.
Howard, L. A., Binks, M. G., Moore, A. P., & Player, J. R. (2000). The contribution of apraxic speech to working memory deficits in Parkinson’s Disease. Brain and Language, 74(2), 269–288.
Huang, M., & et al. (2019). Chapter 2. The reasoning of dysarthria in Parkinson’s disease. In: F. Guo & A. Venkatraman (Eds.), Neurodegenerative Diseases Symptoms and Treatment.
Jiang, D., Li, M., Jiang, L., Chen, X., & Zhou, X. (2019). Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson’s disease: a meta-analysis. Aging Clinical and Experimental Research, 32(5), 769–779. https://doi.org/10.1007/s40520-019-01232-4
Johansson, H., Ekman, U., Rennie, L., Peterson, D. S., Leavy, B., & Franzén, E. (2021). Dual-Task Effects During a Motor-Cognitive Task in Parkinson’s Disease: patterns of Prioritization and the Influence of Cognitive Status. Neurorehabilitation and Neural Repair, 35, 356–366. doi: 10.1177/1545968321999053
Kailash, P., Bain, P., Bajaj, N., Elble, R., Hallett, M., Louis, E., & et al. (2018). Consensus statement on the classification of tremors. from the task force on tremor of the international Parkinson and movement disorder society. Movement Disorders, 33(1), 75–87.
Karlsson, F., & Hartelius, L. (2019). How well does Diadochokinetic task performance predict articulatory imprecision? Differentiating individuals with Parkinson’s disease from control subjects. Folia Phoniatrica et Logopaedica, 71, 251–260. doi: 10.1159/000498851
Kearney, E., Giles, R., Haworth, B., Faloutsos, P., Baljko, M., & Yunusova, Y. (2017). Sentence-level movements in Parkinson’s disease: Loud, clear, and slow speech. Journal of Speech, Language, and Hearing Research, 60(12), 3426–3440. https://doi.org/10.1044/2017_JSLHR-S-17-0075
Kwon, M., & Lee, J. H. (2019). Oro-pharyngeal dysphagia in Parkinson’s disease and related movement disorders. Journal of Movement Disorders, 12(3), 152–160. https://doi.org/10.14802/jmd.19048
Lee, J. (2017). Time course of lexicalization during sentence production in Parkinson’s disease: eye-tracking while speaking. Journal of Speech, Language, and Hearing Research, 60(4), 924–936. https://doi.org/10.1044/2016_jslhr-l-15-0350
Lonneke De Lau, M. L., & Breteler, M. M. B. (2006). Epidemiology of Parkinson’s disease. Lancet Neurology, 5(6), 525–535.
Lowit, A., Marchetti, A., Corson, S., & Kuschmann, A. (2018). Rhythmic performance in hypokinetic dysarthria: Relationship between reading, spontaneous speech and diadochokinetic tasks. Journal of Communication Disorders, 72, 26–39.
Ma, A., Lau, K. K., & Thyagarajan, D. (2020). Voice changes in Parkinson’s disease: what are they telling us? Journal of Clinical Neuroscience, 72, 1–7. doi: 10.1016/j.jocn.2019.12.029
Marsili Luca, Agostino Rocco, Bologna Matteo, Belvisi Daniele, Palma Adalgisa, Fabbrini Giovanni, & Berardelli Alfredo. (2014). Bradykinesia of posed smiling and voluntary movement of the lower face in Parkinson’s disease. Parkinsonism & Related Disorders, 20(4), 370–375.
Mefferd, A. S., & Dietrich, M. (2019a). Tongue- and jaw-specific underpinnings of reduced and enhanced acoustic vowel contrast in talkers with Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 62(7), 2118–2132. https://doi.org/10.1044/2019_JSLHR-S-MSC18-18-0192
Mekyska, J., Janousova, E., Gómez-Vilda, P., Smekal, Z., Rektorova, I., Eliasova, I., & et al. (2015). Robust and complex approach of pathological speech signal analysis. Neurocomputing, 167, 94–111. doi: 10.1016/j.neucom.02.085
Merletti, R. (2001). A novel approach for precise simulation of the EMG signal detected by surface electrodes. IEEE Transactions on Biomedical Engineering, 48, 637–646. doi: 10.1109/10.923782
Merwe, A. V. D. (2009). A Theoretical Framework for the Characterization of Pathological Speech Sensorimotor Control. In: M. R. McNeil (Ed.), Clinical Management of Sensorimotor Speech Disorders (2nd ed., pp. 3–18). Thieme.
Nolden, L. F., Tartavoulle, T., & Porche, D. J. (2014). Parkinson’s disease: Assessment, diagnosis, and management. Journal of the American Association of Nurse Practitioners, 10, 500-506.
Ortiz, K., Brabo, N., & Minett, T. (2016). Sensorimotor speech disorders in Parkinson's disease: Programming and execution deficits. Dementia & Neuropsychologia, 10(3), 210–216. doi: 10.1590/S1980-5764-2016DN1003007
Poewe, W., & et al. (2017). Parkinson disease. Nature Reviews Disease Primers, 23, 17013.
Proulx, M., de Courval, F. P., Wiseman, M. A., & Panisset, M. (2005). Salivary production in Parkinson’s disease. Movement Disorders, 20(2), 204–207.
Rusz, J., Tykalová, T., Klempír, J., Cmejla, R., & RuŽiˇcka, E. (2016). Effects of dopaminergic replacement therapy on motor speech disorders in Parkinson’s disease: longitudinal follow-up study on previously untreated patients. Journal of Neural Transmission, 123, 379–387. doi: 10.1007/s00702-016-1515-8
Sharpe, G., Macerollo, A., Fabbri, M., & Tripoliti, E. (2020). Non-pharmacological treatment challenges in early Parkinson’s disease for axial and cognitive symptoms: a mini review. Frontiers in Neurology, 11, 576569.
Skodda, S., Flasskamp, A., & Schlegel, U. (2010). Instability of syllable repetition as a model for impaired motor processing: Is Parkinson’s disease a “rhythm disorder”? Journal of Neural Transmission, 117, 605–612.
Solomon, N. P., & Hixon, T. J. (1993). Speech breathing in Parkinson’s disease. Journal of Speech and Hearing Research, 36, 294–310.
Suttrup, I., & Warnecke, T. (2015). Dysphagia in Parkinson’s disease. Dysphagia, 31(1), 24-32. https://doi.org/10.1007/s00455-015-9671-9
Theodoros, D. G., Murdoch, B. E., & Thompson, E. C. (1995). Hypernasality in Parkinson’s disease: A perceptual and physiological analysis. Journal of Medical Speech-Language Pathology, 3(2), 73–84.
Tsai, H. W., Chan, P. Y., von Leupoldt, A., & Davenport, P. W. (2013). The impact of emotion on the perception of graded magnitudes of respiratory resistive loads. Biological Psychology, 93(1), 220–224.
Tsanas, A. (2012). Accurate Telemonitoring of Parkinson’s Disease Symptom Severity Using Nonlinear Speech Signal Processing and Statistical Machine Learning. [Unpublished doctoral dissertation]. University of Oxford, Oxford.
Tsanas, A., Little, M. A., Fox, C., & Ramig, L. O. (2014). Objective automatic assessment of rehabilitative speech treatment in Parkinson's disease. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 22(1), 181–190.
Tykalová, T., et al. (2020). Speech disorder and vocal tremor in postural instability/gait difficulty and tremor dominant subtypes of Parkinson’s disease. Journal of Neural Transmission, 127, 1295–1304.
Walshe, M., & Miller, N. (2011). Living with acquired dysarthria: The speaker’s perspective. Disability and Rehabilitation, 33(3), 195–203. https://doi.org/10.3109/09638288.2010.511685
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